9/24/2023 0 Comments Mch neurons mouse brain![]() Blood glucose levels were higher both preprandially and after an intraperitoneal glucose injection. On the FVB genetic background, homozygous transgenic animals fed a high-fat diet ate 10% more and were 12% heavier at 13 weeks of age than wild-type animals, and they had higher systemic leptin levels. To test the hypothesis that chronic overexpression of MCH in mice causes obesity, we produced transgenic mice that overexpress MCH (MCH-OE) in the lateral hypothalamus at approximately twofold higher levels than normal mice. Acute intracerebroventricular injection of MCH increases energy intake in rats. Obese mice lacking functional leptin overexpress the MCH message in the fed or fasted state. Several lines of investigation suggest that the hypothalamic neuropeptide melanin-concentrating hormone (MCH) regulates body weight in mammals. ![]()
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